Splenic marginal zone lymphoma: hydra with many heads?

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Splenic marginal zone lymphoma: hydra with many heads?

In this issue of the Journal, Baseggio et al. 1 report on a series of 24 patients with CD5-positive, t(11;14)-negative splenic marginal zone lymphoma (SMZL) diagnosed by means of cytology and flow cytometry of peripheral blood. All the patients were splenectomized at diagnosis or during follow-up and, consequently, spleen specimens were available for histological examination in all cases. The b...

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Splenic marginal zone lymphoma.

Splenic marginal zone lymphoma (SMZL) is a specific low-grade small B-cell lymphoma that is incorporated in the World Health Organization classification. Characteristic features are splenomegaly, moderate lymphocytosis with villous morphology, intrasinusoidal pattern of involvement of various organs, especially bone marrow, and relative indolent course. Tumor progression with increase of blasti...

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Surgical management of splenic marginal zone lymphoma.

OBJECTIVES Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell lymphoma with variable prognosis. As a result, there is sparse knowledge on the role of splenectomy and best management approaches. We aim to explore management strategies and outcomes amongst the cohort of SMZL patients at our centre. METHOD A retrospective review of all splenectomies performed at a tertiary referral ...

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Unusual Course of Splenic Marginal Zone Lymphoma

A 53-year-old woman was diagnosed with splenic marginal zone lymphoma by pathological examination on left submandibular lymph node and bone marrow biopsies and markedly enlarged spleen. Four cycles of Rituximab chemotherapy were given. Seven months after finishing Rituximab chemotherapy, she developed left upper extremity swelling without evidence of deep venous thrombosis. Repeat PET/CT scan d...

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Splenic Marginal Zone Lymphoma with Concurrent Myelofibrosis: A Case Report

Myelofibrosis associated with lymphoid neoplasms is a rare occurrence with the exception of hairy cell leukemia. Its incidence in splenic marginal zone lymphoma, as we report in this article, has only been reported once in the past. We report the case of a 62 year old male with splenic marginal zone lymphoma and concurrent myelofibrosis. The diagnosis of splenic marginal zone lymphoma was achie...

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ژورنال

عنوان ژورنال: Haematologica

سال: 2010

ISSN: 0390-6078,1592-8721

DOI: 10.3324/haematol.2009.021576